Along these areas are magnificent structures called articular cartilage.

沿着这些区域是称为节软骨的结构。

Okay, so chondrocytes are important for the articular cartilage, got it.

因此软骨细胞对节软骨非常重要。

Maintaining healthy articular cartilage is the chondrocyte's job, a specialized cell responsible for maintaining everything cartilage-related.

保持节软骨的健康是软骨细胞的工作；软骨细胞是负责一切软骨相事务的特殊细胞。

Also, fibrillations form, essentially these cracks or clefts, on what used to be a smooth articular surface.

软骨纤维性颤动也将形成，其本质是这些原本十分光滑的软骨表面出现裂缝或裂口。

Most of the patients are elderly people with chronic articular diseases, like arthritis and ocular problems in particular.

大多数人是老人，有性节，其是节炎和眼。

Whatever the initial cause of articular cartilage damage is, it gets the chondrocytes to start trying to repair the cartilage.

不管引起节软骨损伤的起始因素是什么，会有软骨细胞开始尝试修复软骨。

You can see the articular relationships, there's no question about it.

你可以看到具体的系，这是毫无疑问的。

OA has long been considered the consequence of a 'wear and tear' process leading to loss of articular cartilage.

骨节炎长期以来一直被认为是“磨损”过程的结果，导致节软骨丧失。

The earliest ancestors of mammaliaforms had four bones in their jaws, and the jaw joint was formed by two bones called the articular and the quadrate.

哺乳类动物最早的祖先在颌骨中有四块骨头，颌节由称为节和方骨的两块骨头组成。

Importantly, mutations in cartilage matrix genes such as COL2A1, COL9A3, COL11A2 and cartilage oligomeric matrix protein (COMP), which are produced by articular chondrocytes, cause chondrodysplasia with early-onset OA.

重要的是，软骨基质基因如COL2A1、COL9A3、COL11A2和软骨寡聚基质蛋白（COMP）的突变，这些基因由节软骨细胞产生，会导致软骨发育不良并伴早期发的骨节炎。

Methods c-Fos expression was evaluated by immunohistochemistry on articular cartilage sections from patients with OA and mice subjected to the destabilisation of the medial meniscus (DMM) model of OA.

方法 通过免疫组化评估了来自OA患者和接受内侧半月板不稳(OA的DMM模型)的小鼠的节软骨切片中的c-Fos表达。

How articular chondrocytes, that primarily rely on glycolysis in low oxygen homoeostatic conditions, respond to joint damage and adapt to microenvironmental changes in articular cartilage is an important yet poorly understood question.

节软骨细胞主要依赖于低氧稳态条件下的糖酵解，它们如何响应节损伤并适应节软骨微环境的变化，是一个非常重要但尚不完全理解的问题。

Along with articular cartilage, another important component of synovial joints, and where they get their name from, is the synovium, which along with the surface of the articular cartilage, forms the inner lining of the joint space.

和节软骨一样，滑膜是滑膜节的另一重要组成成分，所以得名“滑膜节”；滑膜分布在节软骨的表面，形成节腔的内层。

Alright, so a healthy joint consists of two bones, each with its own layer of articular cartilage, which is a type of connective tissue that allows the two bones to glide against each other essentially without friction.

好，一个正常的节由两块骨组成；每一块骨有节软骨在外层包绕；节软骨是一种结缔组织，使得两块骨头能基本没有摩擦地互相滑行。

The synovium's composed of loose connective tissue, blood vessels, lymphatic vessels, and on the surface—" Type A" cells that clear cellular debris and " Type B" cells that produce components of synovial fluid, which helps lubricate the two articular surfaces.

滑膜由松散结缔组织、血管、淋巴管组成；在滑膜表面，A型细胞清理细胞碎屑，B型细胞产生滑液成分，滑液能够润滑两块节的表面。